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portada theories of immune networks
Type
Physical Book
Illustrated by
Publisher
Author
Year
2011
Language
English
Pages
117
Format
Paperback
Dimensions
24.2 x 17.3 x 0.8 cm
Weight
0.23 kg.
ISBN
3642839371
ISBN13
9783642839375
Categories

theories of immune networks

Henri Atlan (Illustrated by) · Irun R. Cohen (Illustrated by) · Springer · Paperback

theories of immune networks - Atlan, Henri ; Cohen, Irun R.

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Synopsis "theories of immune networks"

For a long time, immunology has been dominated by the idea of a simple linear cause-effect relationship between the exposure to an antigen and the production of specific antibodies against that antigen. Clonal selection was the name of the theory based on this idea and it has provided the main concepts to account for the known features of the immune response. More recently, immunologists have discovered a wealth of new facts, in the form of different regulatory cells (helpers, suppressors, antigen presenting cells), genetic determinations of immune responses such as those involved in graft re- jections, different molecular structures responsible for intercellular interactions such as interleukins, cytokins, idiotype-antiidiotype recognition and others. While furthering our understanding of the local interactions (molecular and cellular) in- volved in the immune response, these discoveries have led to a questioning of the simplicities of the classical clonal selection theory. It is clear today that every single immune response is a cooperative phenomenon involving several different molecular and cellular interactions taking place in a coupled manner. In addition, cross reactivity to different antigens has shown that responses of the whole im- mune system to different antigens are not completely isolated from one another and that the history of encounters with different antigens plays a crucial role in the maturation of the whole system. Thus, problems of complexity, generation of di- versity and self-organization have entered the field of immunology.

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