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portada The Hypertrophied Heart: Biophysical, Biochemical, and Morphological Aspects of Hypertrophy. International Erwin Riesch Symposium,Tübingen, September 26–29, 1976 (in German)
Type
Physical Book
Publisher
Author
Language
German
Pages
232
Format
Paperback
ISBN13
9783798504820
Edition No.
1

The Hypertrophied Heart: Biophysical, Biochemical, and Morphological Aspects of Hypertrophy. International Erwin Riesch Symposium,Tübingen, September 26–29, 1976 (in German)

Jacob Ruthard (Hg.) (Author) · Steinkopff · Paperback

The Hypertrophied Heart: Biophysical, Biochemical, and Morphological Aspects of Hypertrophy. International Erwin Riesch Symposium,Tübingen, September 26–29, 1976 (in German) - Jacob Ruthard (Hg.)

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Synopsis "The Hypertrophied Heart: Biophysical, Biochemical, and Morphological Aspects of Hypertrophy. International Erwin Riesch Symposium,Tübingen, September 26–29, 1976 (in German)"

Die Umkehr der Calcium-Pumpe des myokardialen sarkoplasmatischen Retikulums (SR) wurde untersucht. SR-Vesikel, die passiv durch Prliinkubation mit hohen Calciumkonzentrationen mit Calcium beladen wurden, synthetisieren ATP aus Orthophosphat und ADP. Die ATP-Synthese erfolgt tiber die Phos- phorylierung der Calcium-Transport-ATPase des SR durch Orthophosphat und eine Dephosphorylierung des E '""" P durch ADP. Die Rate der Calcium-Frei- setzung aus SR-Vesikel - die Calcium-Beladung erfolgte aktiv in Gegenwart von Acetylphosphat - wird durch ADP erhoht. Der ADP-abhlingige Calcium- Efflux ist stochiometrisch mit der ATP-Synthese aus Orthophosphat und ADP gekoppelt. References 1. Suko, J.: The calcium pump of cardiac sarcoplasmic reticulum. Functional alterations at different levels of thyroid state in rabbits. J. Physiol. 228, 563 (1973). 2. Hasselbach, W.: Sarcoplasmic Membrane. ATPase. In: The Enzymes (P. D. Boyer, eds.), N. Y. 10, 431 (1974). 3. Pang, D. C., N. F. Briggs: Reaction mechanism of cardiac sarcotuble calcium dependent adenosin triphosphatase. Biochemistry 12, 4905 (1973). 4. Suko, J., W. Hasselbach: Properties of a phosphorylated intermediate of the 2 Ca -dependent ATPase and ADP-ATP phosphate exchange of cardiac sarco- plasmic reticulum. Naunyn-Schmiedeberg's Arch. Pharmakol. expo Pathol. 282, R. 97 (1974). 5. Suko, J., W. Hasselbach: Characterization of cardiac sarcoplasmic reticulum ATP-ADP phosphate exchange and phosphorylation of the calcium trans- port adenosin triphosphatase. Europ. J. Biochem. 64, 123 (1976). 2 2 6. Suko, J.: The effect of temperature on Ca +-uptake and Ca +-activated ATP hydrolysis by cardiac sarcoplasmic reticulum. Experientia 29, 396 (1973).

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