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portada Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene
Type
Physical Book
Publisher
Author
Year
2020
Pages
76
Format
Paperback
Dimensions
22.90 x 15.20 x 2.50 cm
ISBN13
9780309499248

Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene

Board On Environmental Studies And Toxicology;Engineering, And Medicine National Academies Of Sciences;Division On Earth And Life Studies;Committee To Review Dod's Approach To Deriving An Occupational Exposure Limit For Tce (Author) · National Academies Press · Paperback

Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene - Board on Environmental Studies and Toxicology;Engineering, and Medicine National Academies of Sciences;Division on Earth and Life Studies;Committee to Review DOD's Approach to Deriving an Occupational Exposure Limit for TCE

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Synopsis "Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene"

Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification. Table of ContentsFront MatterSummary1 Introduction2 Approaches to Developing Exposure Values3 Scoping and Problem Formulation4 Hazard Identification5 Quantitative Dose-Response Assessment and Derivation of Occupational Exposure Levels6 ConclusionsAppendix: Biosketches of the Committee

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