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portada Oxidative Stress and Neuroprotection
Type
Physical Book
Publisher
Author
Year
2006
Language
English
Pages
264
Format
Hardcover
Dimensions
27.9x21.3x1.5 cm
Weight
0.98 kg.
ISBN
3211333274
ISBN13
9783211333273
Categories

Oxidative Stress and Neuroprotection

Parvez, S. H. ; Riederer, Peter (Author) · Springer · Hardcover

Oxidative Stress and Neuroprotection - Parvez, S. H. ; Riederer, Peter

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Synopsis "Oxidative Stress and Neuroprotection"

This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson's disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson's therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.

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