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portada Mitochondrial dna Mutations in Aging, Disease and Cancer
Type
Physical Book
Publisher
Author
Language
English
Pages
432
Format
Paperback
ISBN13
9783662125113
Edition No.
1

Mitochondrial dna Mutations in Aging, Disease and Cancer

Singh Keshav K. (Author) · Springer · Paperback

Mitochondrial dna Mutations in Aging, Disease and Cancer - Singh Keshav K.

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Synopsis "Mitochondrial dna Mutations in Aging, Disease and Cancer"

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

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