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portada hydroxy-pyridones as antifungal agents with special emphasis on onychomycosis
Type
Physical Book
Illustrated by
Publisher
Author
Year
1999
Language
English
Pages
109
Format
Paperback
Dimensions
23.4 x 15.6 x 0.6 cm
Weight
0.18 kg.
ISBN
3540654941
ISBN13
9783540654940
Categories

hydroxy-pyridones as antifungal agents with special emphasis on onychomycosis

Sam Shuster (Illustrated by) · Springer · Paperback

hydroxy-pyridones as antifungal agents with special emphasis on onychomycosis - Shuster, Sam

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Synopsis "hydroxy-pyridones as antifungal agents with special emphasis on onychomycosis"

This book presents a series of papers on a special group of antifungal agents - the hydroxypyridones (e.g. Ciclopirox, Rilopirox, and Piroctone) given by international experts at conferences in Vancouver and Sydney. The action of this group of agents is unique. Hydroxypyridones are not only active against all relevant fungi, but they are active against dermato- phytes, yeasts, moulds as well as gram positive and gram negative bacteria. They have an inhibitory effect on the lipoxygenase and cyclo-oxygenase path- ways and, in vitro, exhibit fungicidal and even sporicidal activity. Ciclopirox is particularly able to penetrate keratin. These properties facilitate the treatment not only of tinea pedis caused by fungi but also of infections by gram negative bacteria. The special ability of Ciclopirox to penetrate keratin opens the door to an efficacious topical treat- ment for onychomycosis, with a transungual drug delivery system specially adapted to infections of the nail organ. The absence of drug interactions and systemic side effects of this formulation is an appreciable advantage over the newer systemic therapies for onychomycosis. Papers are presented covering the mode of action, antimicrobial spectrum, pharmacological properties, penetration potential, clinical efficacy and the various indications for this group of drugs. They will enable the reader to as- sess the advantage and disadvantage of this new therapeutic modality.

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