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portada Farnesyltransferase Inhibitors in Cancer Therapy
Type
Physical Book
Publisher
Author
Language
English
Pages
280
Format
Paperback
Dimensions
25.4 x 17.8 x 1.6 cm
Weight
0.52 kg.
ISBN13
9781468496062
Categories

Farnesyltransferase Inhibitors in Cancer Therapy

Sebti, Saïd M. ; Hamilton, Andrew D. (Author) · Humana · Paperback

Farnesyltransferase Inhibitors in Cancer Therapy - Sebti, Saïd M. ; Hamilton, Andrew D.

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Synopsis "Farnesyltransferase Inhibitors in Cancer Therapy"

Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase inhibitors.

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