Advance in Nanoparticles as Vaccine Adjuvants - Eduardo Gomez-Casado;Sohrab Ahmadivand

Remarkable efforts have been made to develop new and improved vaccines that take into account the nature of antigens and the underlying immune mechanisms. Achieving appropriate humoral and cell-mediated immunity requires the development of safe and effective vaccines against infectious diseases and tumour processes. In recent years, increasing attention has been directed toward the use of nanoparticles in vaccine development, as they can protect antigen targets from premature proteolytic degradation, promote homogeneous uptake by immune cells, and facilitate antigen processing and presentation. Nanoparticles composed of lipids, proteins, metals or polymers are already being employed to achieve these properties. This collection brings together recent original research articles and reviews on nanoparticle-loaded vaccines, addressing topics such as their composition, formulation and delivery strategies, safety and efficacy, and the immune responses they elicit. The overarching aim is to advance the development of efficient and long-lasting protection against infectious diseases and tumours.